Sapreme Technologies is a privately-owned biotech company developing a disruptive technology platform (ENDOSCAPE®) enabling the development of superior targeted therapeutics, such as antibody-drug conjugates and oligonucleotide-based drugs.
You will join an ambitious, entrepreneurial team and develop new medicines for cancer and other indications. Projects span both the internal pipeline as well as pharma- and biotech partnered programs, allowing for external interaction.
In this role, you will serve as subject matter expert (SME) and project lead (CRO liaison) for all bioconjugation activities at Sapreme. These projects are aimed at the development of novel complex (ADC-like) bioconjugates with our proprietary endosomal-escape compounds, linker technologies and scaffolds. You will define bioconjugation strategies and lead work packages across all of Sapreme’s projects and pipeline. To this end, you will work in close partnerships with your colleagues from Chemistry, Biologics and Product Development. Work packages are mainly executed at partners and specialty CROs/CDMOs. For work carried out in our state-of-the-art labs, you would serve as SME for lab-based R&D staff, or perform lab-based work yourself.
To excel in this role, the successful candidate will have a solid background in protein chemistry and biochemistry. You should have extensive experience in the development of targeted therapeutics, including but not limited to antibody conjugates, nucleic acid conjugates, and/or protein-nanomaterial conjugates and scaffold-linker technologies. Your expertise and leadership will critically influence Sapreme’s platform development and pipeline. Your expertise in working with proteins and/or protein conjugates will add value to Sapreme, enabling development of a breakthrough technology for intracellular delivery of targeted therapies. In this role, you will directly report to the Principal Scientist Biologics within the Development Department of Sapreme.