Developing next-generation macromolecule therapeutics

Sapreme’s mission is to develop next-generation macromolecule therapeutics by circumventing endosomal entrapment, thereby enhancing target engagement.
The company’s proprietary endosomal escape platform improves the therapeutic window by enabling access to intracellular targets with minimal toxicity.
This approach is applied for Sapreme’s internal pipeline and is available for partnering, without limitation to biologic modality or indication.

Science

The Challenge: Endolysosomal trapping of macromolecules

One of the greatest challenges for efficacy of macromolecule therapeutics that act on an intracellular level, is delivery into key cells. Macromolecule therapeutics nowadays rely on receptor-mediated endocytosis into the endosomal compartment. The endo-lysosomal membranes, however, prohibit efficient cytoplasmic access of such foreign substances. The therapeutic efficacy of such drugs is therefore highly dependent on endo-lysosomal vesicles degradation.
Cytosolic delivery of macromolecule therapeutics requires incredibly challenging technical optimizations or specialized drug delivery platforms. For most oligonucleotide-based therapeutics, delivery remains an unsolved problem and exposes a significant need for the development of novel delivery mechanisms.

Our Approach: ENDOSCAPE®

At Sapreme, we are developing improved macromolecule delivery mechanisms by circumventing endosomal entrapment. Our ENDOSCAPE® platform is based on compounds which can release trapped cargo from the endo-lysosomal membranes, improving the therapeutic window and enabling access to intracellular targets with minimal toxicity.
By binding our technology to antibody-conjugated toxins and oligonucleotides, our goal is to enhance target engagement and improve therapeutic efficacy without limitation to biologic modality or indication.

News & Events

Press Releases:

Sapreme Appoints Henrik Luessen as Chief Business Officer

Utrecht, The Netherlands, January 21, 2021Sapreme, a biotechnology company focused on improving the delivery and efficacy of macromolecule therapeutics, today announced the appointment of Henrik L. Luessen, Ph.D., as Chief Business Officer. In this role, Dr. Luessen will advise Sapreme in its business development, partnerships and funding activities, and will report to Guy Hermans, Ph.D., Chief Executive Officer.

“Henrik brings strong experience with emerging biotechnology companies to Sapreme including licensing, portfolio strategy, financing and strategic development which are critical aspects for Sapreme at this stage of development,” commented Guy Hermans, Chief Executive Officer of Sapreme. “Over the past year, we have been building a strong foundation for our proprietary endosomal escape platform and we look forward to working with Henrik as we discover its extensive applications, both for our internal pipeline and through partnerships.”

“In just one year, Guy has built a strong team and rapidly advanced a unique platform that has the potential to improve the therapeutic profile for a broad range of medicines,” said Henrik Luessen, Chief Business Officer of Sapreme. “It is this broad potential that attracted me to join the company and I am looking forward to contributing my skills and experience to help Sapreme execute on its mission to develop improved therapeutics by circumventing endosomal entrapment.”

Henrik Luessen joins Sapreme through Tytonis B.V., an advisory company specialized in accelerating life science companies, expediting product development and facilitating the introduction of life sciences products. Dr. Luessen previously was Chief Business Officer at Promethera Biosciences, a Belgian biotechnology company focused on cellular and antibody-based treatments to reduce the need for liver transplantation. At Promethera, he was responsible for the scouting and execution of strategic corporate development initiatives, as well as licensing opportunities. Prior to this, Dr. Luessen was Director Business Development at Activaero, a German pharmaceutical company focused on the development of a proprietary smart nebuliser-based technology, and OctoPlus, a leading European provider of advanced drug formulation and clinical scale manufacturing services. Earlier in his career, he was Manager Corporate Development at LTS LOHMANN Therapie Systeme AG. Dr. Luessen is also co-founder of a number of other companies including Dendropharm, Atriva Therapeutics and ICA Aesthetic Navigation.

Dr. Luessen holds a Ph.D. from Leiden/Amsterdam Center of Drug Research in Pharmaceutical Technology, funded by the German National Scholarship Foundation. He graduated as a Pharmacist at University of Hamburg and holds a certification as a Dutch Pharmacist.

Sapreme Appoints Björn Cochlovius as Chairman of its Board of Directors

Utrecht, The Netherlands, December 17, 2020Sapreme, a biotechnology company focused on improving the delivery and efficacy of macromolecule therapeutics, today announced the establishment of its independent Board of Directors by the appointment of Björn Cochlovius, Ph.D., as Chairman of the Board, effective immediately.

“Björn is a pharma industry veteran with both a deep understanding of oncology research and antibody engineering as well as a strong track record of creating value by leading and executing business transactions. Björn’s appointment is particularly timely as his extensive knowledge will aid the advancement of our technology platform through late preclinical development. He will be key in advising the Company in ongoing interactions with potential partners and identifying strategic opportunities that will further validate our approach,” stated Guy Hermans, Chief Executive Officer of Sapreme.

“Sapreme is developing a unique technology that has the potential to be applied to both antibody-conjugated toxins and oligonucleotide therapeutics,” stated Björn Cochlovius, Chairman of Sapreme’s Board of Directors. “I have observed the rapid evolvement of the Company and am impressed by how far the team has come to date. I look forward to supporting the accelerated development of Sapreme’s promising technology with vast potential.”

Dr. Cochlovius brings over two decades of drug discovery, clinical development, commercial and business development experience from the biotechnology and pharmaceutical industries. He currently serves as Chairman of the Board at Isogenica, an antibody discovery biotechnology company specialized in single-domain antibody therapeutics. Additionally, Dr. Cochlovius is Acting Chairman at Karolinska Development, the investment arm of the Karolinska Institute in Stockholm and Associate Professor Immunology at the Reprecht-Karls Universität Heidelberg. Earlier in his career, he held various senior research and development positions, as well as business development and strategic positions at Abbvie Inc., Otsuka, Roche AG, Affitech AS, and others. Dr. Cochlovius began his career developing diabodies and tandem diabodies, or fully recombinant bispecific antibodies, and holds a PhD in Immunology and Oncology from the Universität des Saarlandes.

Sapreme Appoints Miriam Bujny as Chief Development Officer

UTRECHT, The Netherlands, October 27, 2020 Sapreme, a biotechnology company focused on improving the delivery and efficacy of macromolecule therapeutics, today announced the appointment of Miriam Bujny, Ph.D., as Chief Development Officer. With over ten years of experience in drug discovery, translational science and early stage clinical development, Dr. Bujny will apply her expertise in RNA and antibody therapeutic development to further advance Sapreme’s proprietary endosomal escape platform through preclinical development.  Dr. Bujny will be based at Sapreme’s headquarters in Utrecht, The Netherlands, and will report to the CEO.

“Throughout my career, I have seen the limitations of developing promising therapeutic candidates due to the lack of delivery into key cells,” commented Dr. Bujny, Chief Development Officer of Sapreme. “Sapreme is developing a promising platform, that has the ability to improve the delivery and thereby the efficacy for a broad range of macromolecules such as antibody-conjugated toxins and antisense oligonucleotides. I look forward to applying my experience and knowledge toward Sapreme’s mission of developing next-generation macromolecule therapeutics.”

Commenting on the appointment, Guy Hermans, Chief Executive Officer of Sapreme said, “After recently announcing positive preclinical data on our proprietary endosomal escape platform, we are now concentrated on building out our team to accelerate the development of our compounds and identifying the full potential of our platform in the different therapeutic areas. Miriam’s experience in drug discovery and development as well as her demonstrated ability to strategically and operationally lead projects toward the next stage of development will be a valuable asset to us. We welcome Miriam to the team and look forward to working with her.”

Over the last ten years, Dr. Bujny has held leadership positions in various drug discovery and clinical development roles. Prior to joining Sapreme, Miriam worked at ProQR Therapeutics, a Dutch biotech company developing RNA therapies for severe genetic disorders, as Senior Director R&D. During her time at ProQR, she led the early development activities for a novel RNA therapy for Fuchs’ endothelial corneal dystrophy, a common inherited eye disease, from lead candidate optimization toward clinical development preparations. She also headed the Translational Science department and oversaw biomarker and assay development activities across a variety of RNA therapy programs for rare diseases. From 2012 to 2016, she worked in various roles for Janssen, part of the Pharmaceutical Companies of Johnson & Johnson, where she established and headed the predictive biomarker department at the Janssen Prevention Center. Before that, she worked on anti-viral antibody therapy development and contributed to early clinical development as preclinical in vitro lead. Prior to this, Miriam worked at Crucell, before its acquisition by Johnson & Johnson, in the Innovation & Discovery Labs on antibody discovery and engineering.

Dr. Bujny holds a Ph.D. in biochemistry from the University of Bristol with a specialization in endosomal transport. She completed postdoctoral training in the lab of Dr. Xiaowei Zhuang at Harvard University, specializing in developing imaging methods in order to apply them to biomedical questions.

Sapreme Unveils its Proprietary Endosomal Escape Platform in Presentations at 16th Annual Meeting of Oligonucleotide Therapeutics Society

UTRECHT, The Netherlands, September 28, 2020–(BUSINESS WIRE)–Sapreme, a biotechnology company focused on improving the delivery and efficacy of macromolecule therapeutics, today announced positive preclinical data on its proprietary endosomal escape platform in two presentations at the 16th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS), held virtually from September 27th to 30th, 2020.

Sapreme is developing macromolecule delivery methods based on compounds that release therapeutic cargo from the endo-lysosome, improving access to intracellular targets and enhancing the therapeutic window for these therapeutics. Current macromolecular biologics rely on receptor-mediated endocytic uptake into the endosome and inefficient passive release from these vesicles into the cell to achieve therapeutic efficacy. The company’s presentations demonstrate that Sapreme’s SPT001 compound improves intracellular release of targeted antisense oligonucleotides (ASOs) and thereby also their therapeutic efficacy. In addition to ASOs, SPT001 has also been demonstrated to enhance delivery of other targeted payloads such as antibody-conjugated toxins.

“The data presented today underscore the broad potential of our platform to overcome endosomal entrapment and improve the therapeutic window of macromolecule therapeutics,” stated Guy Hermans, Ph.D., Chief Executive Officer of Sapreme. “We are encouraged to see that conjugating SPT001 to liver or tumor targeted ASOs leads to significantly improved silencing, with positive implications for development of metabolic syndrome and oncology targeting drug developments. These results support the further development of SPT001 as the delivery mechanism of choice for future intracellularly active macromolecular drug candidates.”

The presentations are available on demand at the 16th Annual Meeting of the OTS conference website through this link.

The full text press release is available here.

Events:

September 28th, 2020 | Utrecht | The Netherlands

Guy Hermans (CEO) and Ruben Postel (CSO) will be presenting “Efficient, targeted cytoplasmic delivery of oligonucleotides via Sapreme’s endosomal escape enhancers” and “SPT001 enhanced mAb-oligo conjugates: efficient delivery beyond the liver”, respectively, at the 16th Annual Meeting of the Oligonucleotide Therapeutics Society, on Monday, September 28th at 2:15 p.m. EDT.

These presentations will be available on demand through the conference website at this link.

About Sapreme:
Sapreme’s mission is to develop next-generation macromolecule therapeutics by circumventing endosomal entrapment, thereby enhancing target engagement. The company’s proprietary endosomal escape platform improves the therapeutic window by enabling access to intracellular targets with minimal toxicity. This approach is applied for Sapreme’s internal pipeline and is available for partnering, without limitation to biologic modality or indication.

Contacts:
Guy Hermans, CEO
+31 30 760 09 76
hermans@sapreme-technologies.com

For Media Inquiries, please contact:
Trophic Communications
Eva Mulder or Valeria Fisher
+49 89 238 877 30
sapreme@trophic.eu

Careers

If you are a talented individual interested in contributing to our mission, please send your resume to 

info@sapreme-technologies.com

Contact

Telephone

+31 30 760 09 76

Address

LSI, Room 2.09
Yalelaan 62
3584 CM Utrecht
The Netherlands