January 21, 2021
Sapreme Appoints Henrik Luessen as Chief Business Officer
December 17, 2020
Sapreme Appoints Björn Cochlovius as Chairman of its Board of Directors
October 27, 2020
Sapreme Appoints Miriam Bujny as Chief Development Officer
September 28, 2020
Sapreme Unveils its Proprietary Endosomal Escape Platform in Presentations at 16th Annual Meeting of Oligonucleotide Therapeutics Society
September 23rd, 2021
Guy Hermans (CEO) will be speaking at the online SMI Oligonucleotide Therapeutics and Delivery Conference. In his spotlight session titled “Targeted Cytoplasmic Delivery of Oligonucleotides”, he will present how Sapreme’s SPT001 compound enables intracellular delivery of non-membrane permeable biomolecules by enhancing their escape from the endosome.
Furthermore, he will highlight recent proof-of-principle studies on nucleic acid delivery in vitro and in vivo, and provide perspective on ongoing developments.
September 26-29, 2021
Sapreme will be presenting novel validation data on its endosomal escape technology at the upcoming 17th Annual Meeting of the Oligonucleotide Therapeutics Society.
In his short presentation “Efficient on-target delivery of oligonucleotides to the liver and beyond: in vivo performance of Sapreme’s endosomal escape enhancers”, Guy Hermans will showcase data highlighting in vivo gene knock-down in the liver at substantially reduced oligonucleotide doses through the use of SPT001 conjugation technology. Furthermore, results will be shared showing persistence of PD effects, and how tuning of coupling chemistry and SPT001 loading allow for further dose reductions.
June 17th, 2021
Sapreme presented data at the RNAi-Based Therapeutics Summit, demonstrating the potential of its Endosomal Escape Enhancing compound SPT001 to enable superior targeted delivery of oligonucleotides.
Sapreme’s SPT001 compound significantly improves intracellular release of targeted antisense oligonucleotides (ASO’s) and thereby also their therapeutic efficacy. In addition to oligonucleotides, SPT001 has also been demonstrated to enhance delivery of other targeted payloads such as antibody-conjugated toxins. The presentation and Q&A session was hosted on June 17th 2021 via the summit’s virtual stage and platform.
September 28th, 2020
Guy Hermans (CEO) and Ruben Postel (CSO) presented “Efficient, targeted cytoplasmic delivery of oligonucleotides via Sapreme’s endosomal escape enhancers” and “SPT001 enhanced mAb-oligo conjugates: efficient delivery beyond the liver”, respectively, at the 16th Annual Meeting of the Oligonucleotide Therapeutics Society.
Sapreme’s mission is to develop next-generation macromolecule therapeutics by circumventing endosomal entrapment, thereby enhancing target engagement. The company’s proprietary endosomal escape platform improves the therapeutic window by enabling access to intracellular targets with minimal toxicity. This approach is applied for Sapreme’s internal pipeline and is available for partnering, without limitation to biologic modality or indication.
Guy Hermans, CEO
+31 30 760 09 76
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