The Challenge: Endolysosomal trapping of macromolecules

One of the greatest challenges for efficacy of macromolecule therapeutics that act on an intracellular level, is delivery into key cells. Macromolecule therapeutics nowadays rely on receptor-mediated endocytosis into the endosomal compartment. The endo-lysosomal membranes, however, prohibit efficient cytoplasmic access of such foreign substances. The therapeutic efficacy of such drugs is therefore highly dependent on endo-lysosomal vesicles degradation.
Cytosolic delivery of macromolecule therapeutics requires incredibly challenging technical optimizations or specialized drug delivery platforms. For most oligonucleotide-based therapeutics, delivery remains an unsolved problem and exposes a significant need for the development of novel delivery mechanisms.

Our Approach: ENDOSCAPE®

At Sapreme, we are developing improved macromolecule delivery mechanisms by circumventing endosomal entrapment. Our ENDOSCAPE® platform is based on compounds which can release trapped cargo from the endo-lysosomal membranes, improving the therapeutic window and enabling access to intracellular targets with minimal toxicity.
By binding our technology to antibody-conjugated toxins and oligonucleotides, our goal is to enhance target engagement and improve therapeutic efficacy without limitation to biologic modality or indication.

Sapreme Technologies is a privately-owned biotech company developing a disruptive technology platform (ENDOSCAPE^®) enabling the development of superior targeted therapeutics, such as antibody-drug conjugates and oligonucleotide-based drugs. We are currently expanding and have several vacancies to fill. We welcome you to take a look, share with your network, or apply directly.

(Senior) Scientist – Pharmacology/In Vivo Biology You will be responsible for a variety of different preclinical development activities including the translation of early discovery efforts into in vivo proof of concept studies according to industry-standard quality systems. You will contribute to the design of PK/PD studies, you will supervise such studies at specialist CROs, and you are responsible for data interpretation and reporting. The role also encompasses the bioanalysis of study samples, either by setting up and performing select analyses in house or outsourcing to specialty labs. Read the full job description here. We welcome any questions you might have,  please feel free to reach out to the hiring manager Miriam Bujny, or submit your application directly to: careers@sapreme-technologies.com

Scientific writer (part time or full time) As Scientific Writer you will be responsible for providing scientific writing and communication for different research and preclinical activities. You will support the research and development teams by writing research and preclinical study reports, patent examples describing methods and experimental results, and scientific publications (manuscripts, abstracts, presentations, posters, etc.). You will build and manage the internal and external review process of documents and oversee version control and the archiving processes. Next to this, you will maintain an inventory of relevant literature and competitor overviews. You will also be responsible for proofing scientific documents for accurate content before submission to publishers or agencies. To accomplish these objectives, you will closely work with Sapreme’s scientists and leadership and follow-up with relevant stakeholders. Read the full job description here. We welcome any questions you might have,  please feel free to reach out to the hiring manager Miriam Bujny, or submit your application directly to: careers@sapreme-technologies.com

(Senior) Bioconjugation Scientist/Chemist – Conjugate Production and Characterization You will be responsible for producing a variety of customized antibody-drug conjugates, including antibody-protein and antibody-oligonucleotide conjugates. You will optimize the conjugation and purification procedures for a variety of biologics and linkers, according to industry-standard quality processes and systems. You will perform bioanalytical analyses on the resulting conjugates. You will also closely collaborate with the biological validation department to assess the activity of the conjugates. You will accurately report your work and contribute to internal project meetings. Read the full job description here. We welcome any questions you might have,  please feel free to reach out to the hiring manager Ruben Postel, or submit your application directly to: careers@sapreme-technologies.com

Open applications welcome

If you are a talented individual interested in contributing to our mission, please send your resume to careers@sapreme-technologies.com