News & Events

Press Releases:

October 7, 2021

Sapreme Boosts Development of its Endosomal Escape Technology Platform and Proprietary Pipeline with EUR 15M Series A

Sapreme, a biotechnology company focused on improving the delivery and efficacy of macromolecule therapeutics, today announced that it has closed a EUR 15 million Series A financing round to accelerate the buildout of its endosomal escape technology platform and support the further progress of its proprietary pipeline and corporate development activities. Led by founding investor Aglaia Oncology Funds, together with Aglaia-associated partners, the round follows promising 2020 and 2021 preclinical data demonstrating the effectiveness of Sapreme’s endosomal escape compound, SPT001. Read the full release here.


Upcoming events:
20 & 21 April | Boston, MA – 3rd Annual RNAi-based Therapeutics Summit

Guy Hermans (CEO) will be attending, and speaking at the 3rd Annual RNAi-Based Therapeutics Summit.  His presentation on “Efficient on-target delivery of oligonucleotides to the liver and beyond: in vitro performance of Sapreme’s endosomal escape enhancers” at the start of the first day is one not to miss!

25 – 27 April | Boston, MA   – Novel Format Conjugates Summit

Ruben Postel, founder and CSO, will be speaking in person on Tuesday 26th April at the Novel Format Conjugates Summit in Boston, MA. In his talk, he will discuss improved receptor-targeted cytoplasmic delivery of macromolecule payloads using Sapreme’s endosomal escape enhancers.

Past events:
November 29-30, 2021

Sapreme’s Chief Development Officer Miriam Bujny will be speaking at the BioTech Pharma Summit 2021. The topic of her talk will be “Antibody-targeted cytoplasmic delivery of oligonucleotide- or protein conjugates using Sapreme’s endosomal escape enhancers”. She will be presenting data demonstrating how Sapreme’s SPT001 can deliver pharmaceutically relevant amounts of antibodies and antibody conjugates to the cytoplasm or nucleus in a tissue-specific manner, and provide perspective on ongoing developments.

September 23rd, 2021

Guy Hermans (CEO) will be speaking at the online SMI Oligonucleotide Therapeutics and Delivery Conference. In his spotlight session titled  “Targeted Cytoplasmic Delivery of Oligonucleotides”, he will present how Sapreme’s SPT001 compound enables intracellular delivery of non-membrane permeable biomolecules by enhancing their escape from the endosome. Furthermore, he will highlight recent proof-of-principle studies on nucleic acid delivery in vitro and in vivo, and provide perspective on ongoing developments.

September 26-29, 2021

Sapreme will be presenting novel validation data on its endosomal escape technology at the upcoming 17th Annual Meeting of the Oligonucleotide Therapeutics Society. In his short presentation “Efficient on-target delivery of oligonucleotides to the liver and beyond: in vivo performance of Sapreme’s endosomal escape enhancers”, Guy Hermans will showcase data highlighting in vivo gene knock-down in the liver at substantially reduced oligonucleotide doses through the use of SPT001 conjugation technology. Furthermore, results will be shared showing persistence of PD effects, and how tuning of coupling chemistry and SPT001 loading allow for further dose reductions.

About Sapreme:

Sapreme’s mission is to develop next-generation macromolecule therapeutics by circumventing endosomal entrapment, thereby enhancing target engagement. The company’s proprietary endosomal escape platform improves the therapeutic window by enabling access to intracellular targets with minimal toxicity. This approach is applied for Sapreme’s internal pipeline and is available for partnering, without limitation to biologic modality or indication.

Contacts: Guy Hermans, CEO +31 30 760 09 76

For Media Inquiries, please contact: Trophic Communications Eva Mulder or Valeria Fisher +49 89 238 877 30